Scientific Intern, In Vitro Biology

Scientific Intern, In Vitro Biology

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Job Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

The successful candidate will work on a variety tasks and learn what it is like to work in a biotech laboratory environment in a world-class organization. Tasks will include general laboratory duties such as labelling tubes, organizing, and restocking supplies; as well as performing more specialized experimental procedures. Experimental procedures will involve hands-on work with analytical, pre-clinical, and clinical binding assays, including sample preparation, and data analysis. Successful candidate will be given the opportunity to join educational company meetings and events, attend scientific talks given by external experts, observe scientific experiments and learn a great deal. This is a paid internship up to 15 hours per week during school and more hours on summer break as the schedule allows.

Required background:

Must be currently enrolled in a life sciences major at an accredited university at the sophomore or junior level. Must have a strong academic background and a strong GPA.

Great time management skills and must be well organized.

Strong interest in science, learning and working in a fast paced environment.

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

For consideration, please submit your resume and cover letter referencing job 173LG.

Associate Director/Director Upstream Process Development

Associate Director/Director Upstream Process Development

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Position Summary

This position within the Process Sciences group is for an Associate Director/Director, Upstream to lead technology transfer and manufacturing activities at contract manufacturing organizations, and participate in strategic CMC planning and messaging to program teams and Executive Leadership. The candidate will collaborate with Quality, Clinical, and Research functional areas to help advance clinical and pre-clinical programs. The role also requires working closely with Analytical / Formulation and Downstream team members and provide technical guidance for internal upstream protein production operations in a mammalian cell culture lab, and contribute to the development and execution of mammalian cell culture and microbial fermentation processes.

The specific responsibilities include:

  • Developing/directing robust, scalable, well characterized and cost-effective upstream processes for the biologics pipeline
  • Process scale-up, facility fit analysis, optimization studies and successful process transfer
  • Ensure timely GMP manufacture with adherence to Quality Management Systems
  • Technical management of development and manufacturing operations at Contract Development and Manufacturing Organization (CDMOs)
  • Lead process characterization/validation studies (including scale-down models and design of experiment approach to identify critical process parameters) and process validation, including review of development, process characterization and validation protocols and reports
  • Serve as subject matter expert and provide technical expertise to process related trouble-shooting, and Quality support leveraging industry-standard root cause analysis methodologies.
  • Communicate clearly with program stakeholders, technical staff and CDMO partners
  • Ensure high quality source documentation to support global regulatory filings, including writing/reviewing)

Requirements

  • A Master’s or Ph.D. degree (Ph.D. preferred) in Biochemistry, Chemical/Biochemical Engineering, Chemistry, Biological Sciences or other relevant science or engineering field, with at least 10+ years of relevant industrial experience
  • Strong background and subject matter expertise in upstream unit operations including cell line development, fed-batch and perfusion cultures, bioreactor operations, impact of process conditions on product quality, scale-up and large scale manufacturing of recombinant proteins and antibodies
  • Late stage upstream development and contract manufacturing technical management experience
  • Demonstrated large scale mammalian cell culture-based bioprocess, technology transfer and manufacturing experience
  • Experience in upstream process development/manufacturing from microbial systems is also highly desirable
  • Knowledge of cGMP and regulatory requirements related to biologics manufacturing and controls, including authoring relevant CMC sections of IND/BLA filings, is highly desirable
  • Familiarity with statistical software, e.g. JMP is preferred
  • Extremely detail-oriented, thorough, and diligent in experimental design, data analysis and review
  • High level of motivation, initiative and creativity
  • Excellent organizational skills and ability to execute on multiple projects in parallel
  • Excellent written, verbal and presentation communication skills
  • Comfortable working in a high impact, fast-paced and lean biotech start-up environment. Ability to learn and act on dynamic information at a rapid pace.

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

Scientist/Sr. Scientist

Scientist/Sr. Scientist

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Primary Responsibilities:

  • Design and execute MOA studies using methods such as IHC, multi-color flow cytometry, gene expression analysis techniques, MSD and other immunological assays
  • Design, develop, execute and analyze experiments to optimize processes for immune cell expansion and immunological cell-based assays
  • Independently troubleshoot technical issues and develop optimized processes and assays for critical tasks
  • Work together with other departments within the company as well as with external collaborators
  • Be an active participant in internal and external meetings
  • Supervise research associate(s)
  • Contribute to a dynamic, exciting culture that embraces team work and innovation

Skills

  • Ability to independently design, plan, execute and interpret experiments
  • Hands-on experience and troubleshooting proficiency with immune cell isolation from peripheral blood and leukopak, cell expansion, and cell based immunoassays
  • Demonstrated experience with immunological assays to assess and characterize immune cell function such as cytokine secretion, differentiation, activation, cytotoxicity and proliferation and suppression assay
  • Broad expertise in cellular immunology, tumor immunology, molecular biology, IHC/IF Multiplexing and/or flow cytometry
  • Expertise with either IHC/IF (multiplexing) or multi-color flow cytometry (immune cell profiling) and data analysis is required, cell sorting experience a plus

Attributes

  • Proven track record of success through publications and presentations is required
  • Excellent organizational and planning skills
  • Excellent interpersonal, oral and written communication skills are essential in this collaborative environment

Experience

  • PhD with postdoc experience in immunology (0-5 years’ industry experience)
  • Strong background in human/murine immune cell biology is required, with background in oncology a plus

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

For consideration, please submit your resume and cover letter referencing job (#169SP) to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

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