Scientific Intern, In Vitro Biology

Scientific Intern, In Vitro Biology

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Job Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

The successful candidate will work on a variety tasks and learn what it is like to work in a biotech laboratory environment in a world-class organization. Tasks will include general laboratory duties such as labelling tubes, organizing, and restocking supplies; as well as performing more specialized experimental procedures. Experimental procedures will involve hands-on work with analytical, pre-clinical, and clinical binding assays, including sample preparation, and data analysis. Successful candidate will be given the opportunity to join educational company meetings and events, attend scientific talks given by external experts, observe scientific experiments and learn a great deal. This is a paid internship up to 15 hours per week during school and more hours on summer break as the schedule allows.

Required background:

Must be currently enrolled in a life sciences major at an accredited university at the sophomore or junior level. Must have a strong academic background and a strong GPA.

Great time management skills and must be well organized.

Strong interest in science, learning and working in a fast paced environment.

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

For consideration, please submit your resume and cover letter referencing job 173LG.

Sara L. Zaknoen, M.D.

Sara L. Zaknoen, M.D., has served as a director since May 2021. Since June 2014, through her company, Zed Strategic Consulting, Dr. Zaknoen has worked as a clinical drug development consultant with large pharma and biotech companies across multiple disease indications. Previously, Dr. Zaknoen held Chief Medical Officer positions at several biotechnology companies, including Ignyta, Inc., Polynoma LLC, Tragara Pharmaceuticals, Inc. and Cabrellis Pharmaceuticals Corporation. Prior to that, Dr. Zaknoen served as Executive Director of Phase 2/3 Clinical Oncology Research at Novartis Pharmaceutical Corporation, where she provided oversight for a number of important marketed therapies, such as Gleevec®, Tasigna® and Exiade®. This included supervising the execution of clinical studies, including registrational trials, and involvement with new drug applications and label expansion activities. As Director of Clinical Oncology Research at Schering-Plough (now Merck) she was the lead physician on the Temodar® program, supporting its approval and launch. Additional professional experience includes: Assistant Professor of Medicine at the University of Cincinnati Medical Center; Director of Experimental Therapeutics at the Western Pennsylvania Hospital, Western Pennsylvania Cancer Institute; and Medical Staff Fellow at the National Cancer Institute. Dr. Zaknoen completed her residency, internship and fellowship in hematology/oncology at the University of Minnesota. She received her M.D. from Indiana University School of Medicine and her B.S. in chemistry and biology from Valparaiso University.

Associate Director/Director Upstream Process Development

Associate Director/Director Upstream Process Development

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Position Summary

This position within the Process Sciences group is for an Associate Director/Director, Upstream to lead technology transfer and manufacturing activities at contract manufacturing organizations, and participate in strategic CMC planning and messaging to program teams and Executive Leadership. The candidate will collaborate with Quality, Clinical, and Research functional areas to help advance clinical and pre-clinical programs. The role also requires working closely with Analytical / Formulation and Downstream team members and provide technical guidance for internal upstream protein production operations in a mammalian cell culture lab, and contribute to the development and execution of mammalian cell culture and microbial fermentation processes.

The specific responsibilities include:

  • Developing/directing robust, scalable, well characterized and cost-effective upstream processes for the biologics pipeline
  • Process scale-up, facility fit analysis, optimization studies and successful process transfer
  • Ensure timely GMP manufacture with adherence to Quality Management Systems
  • Technical management of development and manufacturing operations at Contract Development and Manufacturing Organization (CDMOs)
  • Lead process characterization/validation studies (including scale-down models and design of experiment approach to identify critical process parameters) and process validation, including review of development, process characterization and validation protocols and reports
  • Serve as subject matter expert and provide technical expertise to process related trouble-shooting, and Quality support leveraging industry-standard root cause analysis methodologies.
  • Communicate clearly with program stakeholders, technical staff and CDMO partners
  • Ensure high quality source documentation to support global regulatory filings, including writing/reviewing)

Requirements

  • A Master’s or Ph.D. degree (Ph.D. preferred) in Biochemistry, Chemical/Biochemical Engineering, Chemistry, Biological Sciences or other relevant science or engineering field, with at least 10+ years of relevant industrial experience
  • Strong background and subject matter expertise in upstream unit operations including cell line development, fed-batch and perfusion cultures, bioreactor operations, impact of process conditions on product quality, scale-up and large scale manufacturing of recombinant proteins and antibodies
  • Late stage upstream development and contract manufacturing technical management experience
  • Demonstrated large scale mammalian cell culture-based bioprocess, technology transfer and manufacturing experience
  • Experience in upstream process development/manufacturing from microbial systems is also highly desirable
  • Knowledge of cGMP and regulatory requirements related to biologics manufacturing and controls, including authoring relevant CMC sections of IND/BLA filings, is highly desirable
  • Familiarity with statistical software, e.g. JMP is preferred
  • Extremely detail-oriented, thorough, and diligent in experimental design, data analysis and review
  • High level of motivation, initiative and creativity
  • Excellent organizational skills and ability to execute on multiple projects in parallel
  • Excellent written, verbal and presentation communication skills
  • Comfortable working in a high impact, fast-paced and lean biotech start-up environment. Ability to learn and act on dynamic information at a rapid pace.

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

Leslie Nangle, Ph.D.

Leslie Nangle, Ph.D., has served as our Vice President, Research since January 2021. Dr. Nangle has served in scientific research roles at aTyr since joining the company in 2007, including most recently as Sr. Director and Head of Research. Dr. Nangle has over 20 years of experience in research dedicated to extracellular tRNA synthetases. Throughout her tenure at aTyr, she has co-developed and implemented the company’s discovery platform to generate an intellectual property estate of over 300 potential therapeutically relevant proteins and has overseen research leading to the discovery of a splice variant of histidyl-tRNA synthetase that has been shown to modulate the immune system, providing the basis of aTyr’s lead program, ATYR1923. Prior to joining aTyr, Dr. Nangle received a Ph.D. in Macromolecular Cellular Structure and Chemistry from The Scripps Research Institute in La Jolla, CA, studying the emerging linkage between mutations in tRNA synthetases and inherited neuropathies under the mentorship of Dr. Paul Schimmel, who co-founded aTyr in 2005. Dr. Nangle received a bachelor of science in biology from the University of California at Santa Barbara. She is co-author or co-inventor of over 75 publications and issued or pending U.S. patents.

Associate Director/Director Upstream Process Development

Associate Director/Director Upstream Process Development

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Position Summary

This position within the Process Sciences group is for an Associate Director/Director, Upstream to lead technology transfer and manufacturing activities at contract manufacturing organizations, and participate in strategic CMC planning and messaging to program teams and Executive Leadership. The candidate will collaborate with Quality, Clinical, and Research functional areas to help advance clinical and pre-clinical programs. The role also requires working closely with Analytical / Formulation and Downstream team members and provide technical guidance for internal upstream protein production operations in a mammalian cell culture lab, and contribute to the development and execution of mammalian cell culture and microbial fermentation processes.

The specific responsibilities include:

  • Developing/directing robust, scalable, well characterized and cost-effective upstream processes for the biologics pipeline

  • Process scale-up, facility fit analysis, optimization studies and successful process transfer

  • Ensure timely GMP manufacture with adherence to Quality Management Systems

  • Technical management of development and manufacturing operations at Contract Development and Manufacturing Organization (CDMOs)

  • Lead process characterization/validation studies (including scale-down models and design of experiment approach to identify critical process parameters) and process validation, including review of development, process characterization and validation protocols and reports

  • Serve as subject matter expert and provide technical expertise to process related trouble-shooting, and Quality support leveraging industry-standard root cause analysis methodologies.

  • Communicate clearly with program stakeholders, technical staff and CDMO partners

  • Ensure high quality source documentation to support global regulatory filings, including writing/reviewing)

Requirements

  • A Master’s or Ph.D. degree (Ph.D. preferred) in Biochemistry, Chemical/Biochemical Engineering, Chemistry, Biological Sciences or other relevant science or engineering field, with at least 10+ years of relevant industrial experience

  • Strong background and subject matter expertise in upstream unit operations including cell line development, fed-batch and perfusion cultures, bioreactor operations, impact of process conditions on product quality, scale-up and large scale manufacturing of recombinant proteins and antibodies

  • Late stage upstream development and contract manufacturing technical management experience

  • Demonstrated large scale mammalian cell culture-based bioprocess, technology transfer and manufacturing experience

  • Experience in upstream process development/manufacturing from microbial systems is also highly desirable

  • Knowledge of cGMP and regulatory requirements related to biologics manufacturing and controls, including authoring relevant CMC sections of IND/BLA filings, is highly desirable

  • Familiarity with statistical software, e.g. JMP is preferred

  • Extremely detail-oriented, thorough, and diligent in experimental design, data analysis and review

  • High level of motivation, initiative and creativity

  • Excellent organizational skills and ability to execute on multiple projects in parallel

  • Excellent written, verbal and presentation communication skills

  • Comfortable working in a high impact, fast-paced and lean biotech start-up environment. Ability to learn and act on dynamic information at a rapid pace.

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

For consideration, please submit your resume and cover letter referencing job 171DL to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

Scientific Intern, Translational Sciences

Scientific Intern, Translational Sciences

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Job Overview

The successful candidate will work on a variety tasks and learn what it is like to work in a biotech laboratory environment in a world-class organization. Tasks will include general laboratory duties such as labelling tubes, organizing, and restocking supplies; as well as performing more specialized experimental procedures. Experimental procedures will involve hands-on work with animal models, sample preparation as well as tissue culture. Successful candidate will be given the opportunity to join educational company meetings and events, attend scientific talks given by external experts, observe scientific experiments and learn a great deal. This is a paid internship up to 15 hours per week during school and more hours on summer break as the schedule allows.

Required background:

Must be currently enrolled in a life sciences major at an accredited university at the sophomore or junior level. Must have a strong academic background and a strong GPA. Great time management skills and must be well organized.

Strong interest in science, learning and working in a fast paced environment.

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

For consideration, please submit your resume and cover letter referencing job 170AB to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

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