tRNA Synthetase Biology

Extracellular tRNA synthetase biology represents a newly discovered set of potential physiological modulators and potential therapeutic intervention points.

Role of these ancient tRNA synthetase genes:

  • Originally, aminoacyl-tRNA synthetases were generally thought to be enzymes with the singular activity of protein synthesis, ensuring that the proper amino acids are used to build proteins
  • In 1999, Dr. Paul Schimmel, our founder, discovered that one of these enzymes included an extracellular signaling region (published in Science in 1999)
  • In 2014, we along with our founders and collaborators, published a paper revealing that extracellular signaling and alternative splicing of tRNA Synthetases occurs in all 23 genes from the tRNA Synthetase family (published in Science in 2014)

aTyr is engaged in the discovery and development of innovative medicines using its knowledge of these newly discovered pathways in immunology effected by extracellular tRNA synthetases.

Click here to read more about tRNA synthetase biology: Publications

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