Publications

Below is a list of relevant publications. Articles with starred (*) titles are available free of charge through the third party link. Within each section, articles are listed most recent first.

Overview

Bi-allelic Mutations in the Phe-tRNA Synthetase Associated with Multi-system Pulmonary Disease Supports Non-Translation Function.

Xu Z, Lo WS, Beck D, Schuch L, Ola´hova´ M, Kopajtich R, Chong Y, Alston C, Seidl E, Zhai L, Lau CF, Timchak D, LeDuc C, Borczuk A, Teich A, Juusola J, Sofeso C, Muller C, Pierre G, Hilliard T, Turnpenny P, Wagner M, Kappler M, Brasch F, Bouffard JP, Nangle L, Yang XL, Zhang M, Taylor R, Prokisch H, Griese M, Chung W, Schimmel P. The American Journal of Human Genetics July 2018 (103): 100–114.

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.

He W, Bai G, Zhou H, Wei N, White NM, Lauer J, Liu H, Shi Y, Dumitru CD, Lettieri K, Shubayev V, Jordanova A, Guergueltcheva V, Griffin PR, Burgess RW, Pfaff SL, Yang XL. Nature 2015 Oct 29;526(7575):710-4.

Human tRNA synthetase catalytic nulls with diverse functions.

Lo WS, Gardiner E, Xu Z, Lau CF, Wang F, Zhou JJ, Mendlein JD, Nangle LA, Chiang KP, Yang XL, Au KF, Wong WH, Guo M, Zhang M, Schimmel P. Science. 2014 Jul 18;345(6194):328-32.

Essential nontranslational functions of tRNA synthetases.

Guo M, Schimmel P. Nat Chem Biol. 2013 Mar;9(3):145-53.

New functions of aminoacyl-tRNA synthetases beyond translation.

Guo M, Yang XL, Schimmel P. Nat Rev Mol Cell Biol. 2010 Sep;11(9):668-74.

Two distinct cytokines released from a human aminoacyl-tRNA synthetase

Wakasugi K, Schimmel P. Science 1999 Apr 2;284(5411):147-51.

Reviews

A tipping point for mistranslation and disease.

Schimmel P, Guo M. Nat Struct Mol Biol. 2009 Apr;16(4):348-9.

Aminoacyl tRNA synthetases and their connections to disease.

Park SG, Schimmel P, Kim S. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11043-9.

An editing activity that prevents mistranslation and connection to disease.*

Schimmel P. J Biol Chem. 2008 Oct 24;283(43):28777-82.

Physiocrine Research

tRNA synthetase: tRNA aminoacylation and beyond.

Pang YL, Poruri K, Martinis SA. Wiley Interdiscip Rev RNA. 2014 Jul-Aug;5(4):461-80.

Leucyl-tRNA synthetase-dependent and -independent activation of a group I intron.

Boniecki MT, Rho SB, Tukalo M, Hsu JL, Romero EP, Martinis SA. J Biol Chem. 2009 Sep 25;284(39):26243-50.

Yeast mitochondrial leucyl-tRNA synthetase CP1 domain has functionally diverged to accommodate RNA splicing at expense of hydrolytic editing.

Sarkar J, Poruri K, Boniecki MT, McTavish KK, Martinis SA. J Biol Chem. 2012 Apr 27;287(18):14772-81.

Functional divergence of a unique C-terminal domain of leucyl-tRNA synthetase to accommodate its splicing and aminoacylation roles.

Hsu JL, Rho SB, Vannella KM, Martinis SA. J Biol Chem. 2006 Aug 11;281(32):23075-82.

Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability.*

Cheng G, Zhang H, Yang X, Tzima E, Ewalt KL, Schimmel P, Faber JE. Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1138-46.

Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine.*

Zhou Q, Kiosses WB, Liu J, Schimmel P. Methods. 2008 Feb;44(2):190-5.

Gain-of-function mutational activation of human tRNA synthetase procytokine.*

Yang XL, Kapoor M, Otero FJ, Slike BM, Tsuruta H, Frausto R, Bates A, Ewalt KL, Cheresh DA, Schimmel P. Chem Biol. 2007 Dec;14(12):1323-33.

Associated Disease Research

Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis.

Zhou JJ, Wang F, Xu Z, Lo WS, Lau CF, Chiang KP, Nangle LA, Ashlock MA, Mendlein JD, Yang XL, Zhang M, Schimmel P. J Biol Chem. 2014 Jul 11;289(28):19269-75.

Role of aminoacyl-tRNA synthetases in infectious diseases and targets for therapeutic development.

Dewan V, Reader J, Forsyth KM. Top Curr Chem. 2014;344:293-329.

Molecular mimicry of human tRNALys anti-codon domain by HIV-1 RNA genome facilitates tRNA primer annealing.

Jones CP, Saadatmand J, Kleiman L, Musier-Forsyth K. RNA. 2013 Feb;19(2):219-29.

Dual role for motif 1 residues of human lysyl-tRNA synthetase in dimerization and packaging into HIV-1.

Dewan V, Wei M, Kleiman L, Musier-Forsyth K. J Biol Chem. 2012 Dec 7;287(50):41955-62.

Formation of the tRNALys packaging complex in HIV-1.

Kleiman L, Jones CP, Musier-Forsyth K. FEBS Lett. 2010 Jan 21;584(2):359-65.

The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.*

Ghanipour A, Jirström K, Pontén F, Glimelius B, Påhlman L, Birgisson H. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2949-56.

Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.*

Storkebaum E, Leitão-Gonçalves R, Godenschwege T, Nangle L, Mejia M, Bosmans I, Ooms T, Jacobs A, Van Dijck P, Yang XL, Schimmel P, Norga K, Timmerman V, Callaerts P, Jordanova A. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11782-7.

Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect.*

Nangle LA, Zhang W, Xie W, Yang XL, Schimmel P. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11239-44.

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.*

Xie W, Nangle LA, Zhang W, Schimmel P, Yang XL. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):9976-81.

tRNA Synthetase Structural Research

Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing.

Xu Z, Wei Z, Zhou JJ, Ye F, Lo WS, Wang F, Lau CF, Wu J, Nangle LA, Chiang KP, Yang XL, Zhang M, Schimmel P. Structure. 2012 Sep 5;20(9):1470-7.

Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality.*

Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL. Nat Struct Mol Biol. 2010 Jan;17(1):57-61.

Functional expansion of human tRNA synthetases achieved by structural inventions.*

Guo M, Schimmel P, Yang XL. FEBS Lett. 2010 Jan 21;584(2):434-42.

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