Physiocrine biology represents a newly discovered set of potential physiological modulators and potential therapeutic intervention points.
Through our discovery efforts, we believe that Physiocrines naturally evolved over billions of years to promote homeostasis and reset the immune system and other physiological systems to control or reduce tissue damage while maintaining the immune system’s normal activity.
Role of these ancient tRNA Synthetase Genes:
- Originally, aminoacyl-tRNA Synthetases were generally thought to be enzymes with the singular activity of protein synthesis, ensuring that the proper amino acids are used to build proteins
- In 1999, Dr. Paul Schimmel, our founder, discovered that one of these enzymes included an extracellular signaling region (published in Science in 1999)
- In 2014, we along with our founders and collaborators, published a paper revealing that extracellular signaling and alternative splicing of tRNA Synthetases occurs in all 23 genes from the tRNA Synthetase family (published in Science in 2014)
- We refer to these extracellular signaling regions of tRNA synthetases, along with splice-variants of the regions of tRNA synthetases, as Physiocrines
We have continued research in this field and have discovered over ~300 Physiocrine proteins potentially involved in physiological pathways.